POSTSCRIPT-Issue 2

Track: early signs and symptoms, labs
Why: Early awareness and action improve outcomes

Issue 2: Beyond Keto: The Real Science of Insulin Resistance

Here’s the “Loh-down” on Insulin Resistance

Insulin resistance is not just about carbs. It’s about excess free fatty acids, toxic lipid intermediates, and tissues refusing insulin’s signal — all long before blood sugar rises.
Hyperinsulinemia is the warning light. Think 10 workers lifting the same trash can one used to handle alone: the system looks “normal” until it suddenly doesn’t.
Ketones are more than fuel. They’re signaling molecules that calm inflammation, support failing hearts, and reprogram immune cells. In excess of fuel demand, they can be converted back to fat for storage.
Most “keto diets” aren’t truly ketogenic. Clinical ketogenic diets are tightly controlled; what most people call “keto” is just low-carb with extra protein.
Supplements promise shortcuts. Ketone esters, salts, and MCTs raise ketones for hours, but don’t reproduce nutritional ketosis.
The frontier: Trials are probing ketones for heart failure, dementia, kidney disease, and immune modulation. Results are intriguing, and hopefully will pave the way for future research.

Bottom line: Metabolism is complex and involves various concurrent pathways. It should be seen in the context of defined states (‘fed’ vs. ‘fasting’. for example) whereby a net effect might be determined.

This Month’s Challenge: Re-design your eating plan

Over the next 3 weeks, Wellth-e will include a weekly practical checklist — step-by-step, science-backed actions you can take to improve your metabolic health. Think of these as your Wellthe Workbook in motion. Each supplement will include:

–Pro-tips for making changes sustainable

–Checklist of swaps to make that week.

Week 1 — Spotting Insulin Resistance Early